NMN

Description

ß-Nicotinamide mononucleotide (NMN) is a supplement derived from the essential B-vitamin niacin. As a dynamic precursor to nicotinamide adenine dinucleotide (NAD+), NMN plays a crucial
role in enhancing the synthesis of NAD+ which is found in every cell in our bodies. Noted for its stability and sustained effectiveness beyond NAD+, NMN boosts cellular energy production and
overall cell health. This not only revitalizes energy levels but also specifically aids in managing age-related conditions such as hearing and vision loss.

Moreover, NMN plays a key role in activating our sirtuin genes, which are linked to longevity and slowing of the aging process. Embrace the rejuvenating power of NMN to bolster your body’s health at the cellular level, offering a comprehensive approach to aging with vitality and resilience.

Potential Benefits of NMN

• ANTI-AGING AND HEALTH-ENHANCING EFFECTS: NMN can reduce weight gain related to aging, boost energy metabolism, enhance insulin sensitivity, enhance eye function, improve mitochondrial metabolism, and counteract changes in gene expression that occur with aging.
• IMPROVED TISSUE AND ORGAN FUNCTION: NMN is believed to support the health of various tissues and organs by enhancing cellular energy production and reducing cellular stress, which are critical for maintaining organ health.
• PROTECTION FROM COGNITIVE DECLINE: By boosting NAD+ levels, NMN may help maintain neuronal integrity and function, potentially protecting against age-related cognitive decline.
• IMPROVED METABOLIC HEALTH: NMN may promote metabolic health by improving insulin sensitivity, reducing weight gain, and enhancing energy metabolism, which are crucial for managing conditions like diabetes and obesity.
• REDUCED INFLAMMATION: NMN has been shown to reduce markers of inflammation in the body. Chronic inflammation is linked to many age-related diseases and reducing it can help maintain overall health.
• INCREASED PHYSIOLOGICAL BENEFITS: Supplementing with NMN could enhance physical activity levels by improving muscle function and energy levels, further contributing to a healthier and more active lifestyle.

Improving cellular health and longevity¹

• ACTIVATION OF SIRTUINS: Sirtuins are a family of enzymes that require NAD+ to function.
• REGULATION OF GENE EXPRESSION: Sirtuins influence gene expression by modifying chromatin structure of DNA, sirtuins can either promote or suppress the transcription of genes involved in aging, metabolic regulation, and stress resistance.
• STRESS RESPONSE AND DNA REPAIR: Sirtuins also help cells respond to stress and repair damaged DNA.
• INFLUENCE ON LONGEVITY AND AGING: Research has shown that activating sirtuins can mimic the effects of caloric restriction, a known factor that can extend lifespan in various organisms. By increasing NAD+ levels, and thereby enhancing sirtuin activity, cells can potentially gain increased resistance to aging and associated diseases.

Suggested Dose:
Take 1 to 2 capsules by mouth one time daily

Other Ingredients:
Hypromellose, Microcrystalline Cellulose, Magnesium Stearate, Silicone Dioxide

Safety and Tolerability²,³ :
* Side effects are generally mild and include abdominal pain, bloating, diarrhea, and upper respiratory tract symptoms.

References:

1. Covarrubias AJ, Perrone R, Grozio A, et al. NAD+ metabolism and its roles in cellular processes during aging. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141.
2. Okabe K, Yaku K, Uchida Y, et al. Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Front Nutr. 2022 Apr 11;9:868640.
3. Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: A randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023 Feb;45(1):